Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?
نویسندگان
چکیده
منابع مشابه
Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?
Aortic stenosis is the most common adult heart valve condition seen in the Western world and its incidence continues to rise. No established disease modifying treatments retard progression of the stenotic process. Recent insights into the pathogenesis of calcific aortic stenosis suggest that the disease mimics atherosclerosis. The natural history and progression of calcific aortic stenosis are ...
متن کامل[Medical treatments in aortic stenosis: role of statins and angiotensin-converting enzyme inhibitors].
CALCIFIC AROTIC STENOSIS AND ATHEROSCLEROSIS: Aortic stenosis is the most frequent valvular heart disease in western world and its incidence continues to rise. Aortic sclerosis is the first characteristic lesion of the cusps, which is today considered a process similar to atherosclerosis. The progression of the disease is an active process leading to forming of bone matrix and heavily calcified...
متن کاملStatins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis.
BACKGROUND Recently, statins and angiotensin-converting enzyme inhibitors (ACEIs) have been shown to slow aortic valve calcium accumulation. Although several studies also suggest that statins may reduce the hemodynamic progression of aortic stenosis (AS), no data are available for ACEIs or the combination of both. METHODS AND RESULTS A total of 211 consecutive patients (aged 70+/-10 years, 10...
متن کاملAngiotensin converting enzyme inhibitors and angiotensin receptor (AT1) antagonists: either or both for primary renal disease?
At the present time we cannot assume that the proven benefits of ACEI on renal disease will be reproduced by using AT1-ra. With potentially differing modes of activity of these drugs, they cannot be seen as interchangeable and ACEI should remain the drug of choice in patients with progressive renal disease unless they are not tolerated. It is possible that AT1-ra may offer additional advantages...
متن کاملAngiotensin converting enzyme inhibitors.
The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected t...
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ژورنال
عنوان ژورنال: Heart
سال: 2005
ISSN: 1355-6037
DOI: 10.1136/hrt.2005.066852